Autophagy Activation by Rapamycin Before Hypoxia-Reoxygenation Reduces Endoplasmic Reticulum Stress in Alveolar Epithelial Cells
Background: To determine potential effects of autophagy activation on hypoxia-reoxygenation (H/R) induced damage of a rat Jumpsuit alveolar epithelial cell line.Methods: CCL149 cells were subjected to autophagy agonist (rapamycin, Rap), autophagy inhibitor (3-methyladenine, 3-MA) or PBS for 1 h before H/R treatment for 2 h, 4 h and 6 h.The optimal